Steroids and various topical therapies with hardly any response. In the past, she had received PUVA sol, systemic For vitiligo, she was not receiving any therapy for the last 10 years. DCP regimen isĪ well-regarded therapy for pemphigus in India. DCP regimen comprises monthly intravenous dexamethasone (140 mg) given over 3 consecutive days and intravenousĬyclophosphamide (500 mg) given on day 2, and oral cyclophosphamide (1 mg/kg/day) in the intervening period. With this diagnosis, she was started on dexamethasone cyclophosphamide Lesion was consistent with the diagnosis of pemphigus vulgaris. Sign was positive and Tzanck smear from the blister showed the presence of acantholytic cells. On examination, lesions were present over herįace, scalp, trunk, and limbs in the form of flaccid bullae, the majority of which had ruptured leaving raw erosions. Of 4-months and vesiculobullous lesions over her body of 2-months duration.
Vitiligo universalis skin#
Pigmentation of the vitiliginous skin over the face.Ī 50-year-old woman, known to have vitiligo universalis of 37-years duration, presented with history of painful oral ulceration With dexamethasone cyclophosphamide pulse (DCP) therapy. We report an interesting observation made in the vitiliginous skin of an Indian patient being treated for pemphigus vulgaris Vitiligo is an acquired disorder of pigmentation of great cosmetic concern having unpredictable course with an estimated worldwide Melanocytes can recover their functionality in vivo and in vitro under an appropriate stimulus. Our observations indicate that melanocytes are never completely absent in the depigmented epidermis and that these In the vitiliginous skin of an Indian patient being treated for pemphigus vulgaris with dexamethasone cyclophosphamide pulse We report an interesting observation made Recent reports suggest that vitiligo lesions are not totally devoid of melanocytes.
Sunil Dogra MD, and Bhushan Kumar MD Dermatology Online Journal 11 (3): 30 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, Repigmentation in vitiligo universalis: Role of melanocyte density, disease duration, and melanocytic reservoir
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